Located at the University of Illinois-Chicago, the Sharma Lab explores how the nervous system controls motor behaviors, including locomotion, breathing, and sleep.
The videos below demonstrate the powerful effects of V2a neurons, which have been shown to regulate limb coordination and breathing. Typical mice have V2a neurons. Steven Crone, a past member of the lab, generated mice in which their V2a neurons are genetically ablated. These mice show strikingly different gait at high speeds. Watch the mice run at slow speed in the first two videos and high speed in the last two, and note that mice without V2a neurons move left and right legs simultaneously.